Specific functions of the SLC1A family in lung cancer are still not systematically described. The Solute Carrier 1A (SLC1A) family play a significant part in cellular biological process, inflammation, and immunity. Lung adenocarcinoma (LUAD) is the most common dangerous malignant tumor and the leading cause of global cancer incidence and mortality. SLC1A3 is therefore a potential therapeutic target in gastric cancer. Our findings indicate that SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway. The PI3K/AKT inhibitor LY294002 prevented SLC1A3-induced glucose metabolism and cell proliferation. SLC1A3 overexpression activated the PI3K/AKT pathway and up-regulated GLUT1, HK II and LDHA expression. GSEA analysis suggested that SLC1A3 was positively associated with the up-regulation of the PI3K/AKT pathway. In vitro and in vivo assays showed that SLC1A3 affected glucose metabolism and promoted gastric cancer growth. SLC1A3 was found to be overexpressed in gastric cancer, and this overexpression was associated with poor prognosis. The roles of SLC1A3 in tumour growth were evaluated using a xenograft tumour growth model. Glucose consumption, lactate excretion and ATP levels were determined. SLC1A3 overexpressing and knock-down cell lines were constructed, and the cell viability was evaluated. The expression levels of SLC1A3 were examined using RT-qPCR and Western bolting. We used bioinformatics approaches to analyse the expression of SLC1A3 and its role in gastric cancer. The glutamate/aspartate transporter SLC1A3 has been implicated in tumour metabolism and progression, but the roles of SLC1A3 in gastric cancer remain unclear. The chiller has suction-gas cooled, hermetic, scroll compressors.Gastric cancer is a major cause of mortality worldwide.
#York ycal 007c style c code#
Units are designed in accordance with NFPA 70 (National Electric Code),ASHRAE/ANSI 15 Safety code for mechanical refrigeration,ASME, Listed and labeled with Intertek Testing Services (ETL) and rated in accordance with ARI Standard 550/590-2003. Corrosion resistant wire mesh panels are added to protect the condenser coil from incidental damage and restrict unauthorized access to internal components. The unit structure is heavy-gauge, galvanized steel.This galvanized steel is coated with baked-on powder paint, which, when subjected to ASTM B117 1000 hour, salt spray testing, yields a minimum ASTM 1654 rating of “6”. After assembly, a complete operational test is performed with water flowing through the cooler to assure that the refrigeration circuit operates correctly.
The unit is pressure-tested, evacuated, and fully charged with Refrigerant-22 (HCFC-22) and includes an initial oil charge. The 47 - 60 Ton (165 - 210 kW) YCAL models are shipped complete from the factory ready for installation and use.
Power Wiring.Ĭontrol Wiring.Īpplication Data. Isolator Details (cont'd).Įlectrical Data.Įlectrical Data - 60Hz.Įlectrical Data - 50Hz. Sound Data.ĭimensions - YCAL0041 (English).ĭimensions - YCAL0045 (English).ĭimensions - YCAL0051 (English).ĭimensions - YCAL0055EC - (English).ĭimensions - YCAL0061 (English).ĭimensions - YCAL0065 (English).ĭimensions - YCAL0041 (SI). Part Load Ratings - R-22 (English Units). Ratings - R-22 (50Hz - English Units) - Cont. Ratings - R-22 (60Hz - English Units) - Cont. Ratings - R-22 (50Hz - English Units) - Cont.Ratings - R-22 (60Hz - English Units) - Cont.